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Results for "

microglial cell

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

11

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7006
    Timosaponin C

    Anemarsaponin C

    		 Others Inflammation/Immunology
    Timosaponin C is isolated from Rhizoma Anemarrhenae . Timosaponin C shows weaker NO inhibition in N9 microglial cells .
    Timosaponin C
  • HY-107617
    PTIQ

    		MMP Neurological Disease
    PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells .
    PTIQ
  • HY-155572
    Nrf2 activator-8

    		Keap1-Nrf2 Inflammation/Immunology
    Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .
    Nrf2 activator-8
  • HY-18730
    1400W

    W1400

    		 NO Synthase Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
    1400W
  • HY-110099
    (±)-NBI-74330

    		CXCR Inflammation/Immunology
    (±)-NBI-74330 is a potent and selective CXCR3 antagonist. (±)-NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (±)-NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model .
    (±)-NBI-74330
  • HY-18731
    1400W Dihydrochloride
    10+ Cited Publications

    		 NO Synthase Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
    1400W Dihydrochloride
  • HY-147512
    CB1/2 agonist 1

    		Cannabinoid Receptor Inflammation/Immunology
    CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC50s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis .
    CB1/2 agonist 1
  • HY-N10066
    Anti-inflammatory agent 5

    		Others Inflammation/Immunology
    Anti-inflammatory agent 5 displays potent inhibition of NO generation in lipopolysaccharide-induced BV-2 microglial cells.
    Anti-inflammatory agent 5
  • HY-N3760
    Dimeric coniferyl acetate

    		NO Synthase Inflammation/Immunology
    Dimeric coniferyl acetate is a NO production inhibitor with an IC50 value 7.9 μM in BV-2 microglial cells .
    Dimeric coniferyl acetate
  • HY-N3473
    Isomaculosidine

    		NO Synthase Neurological Disease
    Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .
    Isomaculosidine
  • HY-N1713
    29-Nor-20-oxolupeol

    29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC50 of 44.21 µM .
    29-Nor-20-oxolupeol
  • HY-N10275
    Herpotrichone A

    		Others Inflammation/Immunology
    Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.41 μM.
    Herpotrichone A
  • HY-N8936
    Narchinol B

    		Others Inflammation/Immunology
    Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC50=2.43 μM) .
    Narchinol B
  • HY-N10274
    Herpotrichone B

    		Others Neurological Disease Inflammation/Immunology
    Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.11 μM.
    Herpotrichone B
  • HY-148853
    SRI-42127

    		HuR Others
    SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .
    SRI-42127
  • HY-152026
    NADPH oxidase-IN-1

    		NADPH Oxidase Neurological Disease
    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .
    NADPH oxidase-IN-1
  • HY-138050
    Nyasol

    (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol

    		 NO Synthase Bacterial Fungal Parasite Leukotriene Receptor Infection Inflammation/Immunology
    Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
    Nyasol
  • HY-101364
    CHPG

    		mGluR NF-κB ERK Akt Cardiovascular Disease Inflammation/Immunology
    CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways .
    CHPG
  • HY-101364A
    CHPG sodium salt

    		mGluR NF-κB ERK Akt Neurological Disease Inflammation/Immunology
    CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. .
    CHPG sodium salt
  • HY-146168
    Nrf2 activator-5

    		Keap1-Nrf2 Inflammation/Immunology
    Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .
    Nrf2 activator-5
  • HY-N8371
    Shizukaol B

    		NO Synthase COX Interleukin Related TNF Receptor Inflammation/Immunology
    Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .
    Shizukaol B
  • HY-10512S
    AR-A014418-d3

    AR 0133418-d3; GSK 3β inhibitor VIII-d3; AR 014418-d3

    		 Isotope-Labeled Compounds GSK-3 Metabolic Disease Cancer
    AR-A014418-d3 is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].
    AR-A014418-d3
  • HY-N2259
    Curcumenol
    2 Publications Verification

    (+)-Curcumenol
    Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells .
    Curcumenol
  • HY-N4190
    Britannilactone diacetate

    1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone

    		 NO Synthase Neurological Disease Inflammation/Immunology
    Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property .
    Britannilactone diacetate
  • HY-N10429
    Geissoschizoline

    (+)-Geissoschizoline

    		 Cholinesterase (ChE) Neurological Disease Inflammation/Immunology
    Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent .
    Geissoschizoline
  • HY-114153
    PLX5622
    Maximum Cited Publications
    38 Publications Verification

    		 c-Fms Neurological Disease
    PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is mostly used in the way of feed free diet (HY-114153C) .
    PLX5622
  • HY-B0130A
    Perindopril erbumine
    4 Publications Verification

    Perindopril tert-butylamine salt; S-9490 erbumine

    		 Sirtuin NF-κB STAT Angiotensin-converting Enzyme (ACE) Cardiovascular Disease Cancer
    Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
    Perindopril erbumine
  • HY-B0130AS
    Perindopril-d3 erbumine

    Perindopril-d3 tert-butylamine salt; S-9490-d3 erbumine

    		 NF-κB STAT Sirtuin Angiotensin-converting Enzyme (ACE) Isotope-Labeled Compounds Cardiovascular Disease Cancer
    Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
    Perindopril-d3 erbumine
  • HY-B0130
    Perindopril
    4 Publications Verification

    S-9490

    		 Angiotensin-converting Enzyme (ACE) NF-κB STAT Sirtuin Cardiovascular Disease Neurological Disease Cancer
    Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
    Perindopril

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